fevereiro 06, 2011

Invisíveis passageiros

O pessoal já fez as contas: de cada 10 células no seu corpo, apenas uma é sua!
O resto são microorganismos!
Vc é apenas o piloto deste ônibus de bactérias.
Nada mais natural que estes passageiros influam na sua saúde, no seu humor, na sua aparência e até mesmo na sua longevidade na medida em que interagem com seu sistema imune.
Tal conclusão não era nem mesmo imaginada há cerca de 10 anos atrás.
Um novo enfoque sobre a origem dos nossos males está apenas no seu alvorecer.
Para quem gosta do tema, selecionei para divulgar, 03 textos muito legais da Science.
Abaixo de cada título, um fragmento do texto original para aumentar a sua curiosidade


Body’s Hardworking Microbes Get Some Overdue Respect
www.sciencemag.org SCIENCE VOL 330 17 DECEMBER 2010

HUMANS HAVE BEEN DOING BATTLE WITH bacteria since the 1800s, thwarting disease with antibiotics, vaccines, and good hygiene with mixed success. But in 2000, Nobel laureate Joshua Lederberg called for an end to the “We good; they evil” thinking that has fueled our war against microbes.
“We should think of each host and its parasites as a superorganism with the respective genomes yoked into a chimera of sorts,” he wrote in Science in 2000. His comments were prescient. This past
decade has seen a shift in how we see the microbes and viruses in and on our bodies. There is increasing acceptance that they are us, and for good reason. Nine in 10 of the cells in the body are microbial. In the gut alone, as many as 1000 species bring to the body 100 times as many genes as our own DNA carries. A few microbes make us sick, but most are commensal and just call the
human body home. Collectively, they are known as the human microbiome. Likewise, some viruses take up residence in the body, creating a virome whose infl uence on health and disease is just beginning to be studied.


Inflammation Bares a Dark Side
www.sciencemag.org SCIENCE VOL 330 17 DECEMBER 2010


NOT LONG AGO, INFLAMMATION HAD A CLEAR role: It was a sidekick to the body’s healers, briefl y setting in as immune cells rebuilt tissue damaged by trauma or infection. Today,
that’s an afterthought. Infl ammation has hit the big time. Over the past decade, it has become widely accepted that infl ammation is a driving force behind chronic diseases that will kill nearly all of us. Cancer. Diabetes and obesity. Alzheimer’s disease. Atherosclerosis.
Here, infl ammation wears a grim mask, shedding its redeeming features and making sick people sicker.


Inflammation and Cancer: The Link Grows Stronger
Research into a long-suspected association between chronic inflammation and cancer
reveals how the immune system may be abetting tumors
www.sciencemag.org SCIENCE VOL 306 5 NOVEMBER 2004

Hepatitis B virus infects hundreds of millions of people worldwide, causing jaundice, fatigue, liver damage, and joint pain. More ominously, investigators have indicted it in another role: as co-conspirator in a farranging case they’ve been building for years linking chronic inflammation and cancer. Researchers have long known that patients with persistent hepatitis B infections experience
inflammation and scarring of liver tissue and an increased risk of liver cancer. Other sources of chronic inflammation, including the ulcer-causing bacterium Helicobacter pylori and an immune disorder known as ulcerative colitis, predispose patients to cancers of the stomach and colon.
Based on their experience with these diseases, researchers estimate that inflammation contributes to the development of at least 15% of all cancers. Much less clear, however, is exactly how it does its dirty work. The inflammation-cancer connection is especially puzzling in light of other work suggesting
that in some circumstances the immune system, which sustains inflammation, has the opposite
effect: inhibiting tumor development. A flurry of results published over the past few months may now be resolving the mystery

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