Olha o que catei na internet!!!
Encontraram uns caras daqui de Salvador...
Estão tocando na Ponta do Humaitá,um dos postais da nossa cidade!!!
O site como todo vale a pena curtir...
LM
Playing For Change | Samba de Viola
Abaixo, trabalho Brazuca sobre atividade física e inflamação em mais um post da minha cruzada contra o organismo remoso:
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Eduardo R. Ropelle1, Marcelo B. Flores1, Dennys E. Cintra1, Guilherme Z. Rocha1, José R. Pauli1, Joseane Morari1, Claudio T. de Souza1, Juliana C. Moraes1, Patrícia O. Prada1, Dioze Guadagnini1, Rodrigo M. Marin1, Alexandre G. Oliveira1, Taize M. Augusto2, Hernandes F. Carvalho2, Lício A. Velloso1, Mario J. A. Saad1, José B. C. Carvalheira1*
1 Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil, 2 Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Abstract Top
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKβ activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKβ/NF-κB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin and leptin resistance. This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKβ/NF-κB signaling and ER stress. We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. Moreover, in contrast to control mice, exercise failed to reverse the pharmacological activation of IKKβ and ER stress in C3H/HeJ mice deficient in hypothalamic IL-6 and IL-10 signaling. Hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin.
Discussion
Exercise as a Potential Target for Countering Hyperphagia and Obesity
Physical activity is a cornerstone in the prevention of obesity and related diseases. Although the energy expenditure aspects of such exercise may contribute to the effects of weight loss, it has been suggested that physical exercise may also contribute to negative energy balance by altering appetite and reducing food intake in rodents [21],[32] and humans [33],[34]. Our study shows that acute exercise per se did not evoke any meaningful effect, in terms of food intake in lean animals, but interestingly, it was crucial for suppressing hyperphagia mediated by overnutrition, reducing hypothalamic IKKβ/NF-κB activation and ER stress, thus improving insulin and leptin action in an IL-6- and IL-10-dependent manner...
Arigo completo aqui: http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000465
P.S. Se derrotarmos o organismo remoso acabaremos com 99% dos problemas da humanidade!
Playing For Change | Samba de Viola
Abaixo, trabalho Brazuca sobre atividade física e inflamação em mais um post da minha cruzada contra o organismo remoso:
IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition
Eduardo R. Ropelle1, Marcelo B. Flores1, Dennys E. Cintra1, Guilherme Z. Rocha1, José R. Pauli1, Joseane Morari1, Claudio T. de Souza1, Juliana C. Moraes1, Patrícia O. Prada1, Dioze Guadagnini1, Rodrigo M. Marin1, Alexandre G. Oliveira1, Taize M. Augusto2, Hernandes F. Carvalho2, Lício A. Velloso1, Mario J. A. Saad1, José B. C. Carvalheira1*
1 Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil, 2 Department of Anatomy, Cell Biology, Physiology and Biophysics, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Abstract Top
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKβ activation and endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia and associated hypothalamic IKKβ/NF-κB activation by a mechanism dependent upon the pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked the beneficial effects of exercise on the re-balance of food intake and insulin and leptin resistance. This molecular mechanism, mediated by physical activity, involves the anti-inflammatory protein IL-10, a core inhibitor of IKKβ/NF-κB signaling and ER stress. We report that exercise and recombinant IL-6 requires IL-10 expression to suppress hyperphagia-related obesity. Moreover, in contrast to control mice, exercise failed to reverse the pharmacological activation of IKKβ and ER stress in C3H/HeJ mice deficient in hypothalamic IL-6 and IL-10 signaling. Hence, inflammatory signaling in the hypothalamus links beneficial physiological effects of exercise to the central action of insulin and leptin.
Discussion
Exercise as a Potential Target for Countering Hyperphagia and Obesity
Physical activity is a cornerstone in the prevention of obesity and related diseases. Although the energy expenditure aspects of such exercise may contribute to the effects of weight loss, it has been suggested that physical exercise may also contribute to negative energy balance by altering appetite and reducing food intake in rodents [21],[32] and humans [33],[34]. Our study shows that acute exercise per se did not evoke any meaningful effect, in terms of food intake in lean animals, but interestingly, it was crucial for suppressing hyperphagia mediated by overnutrition, reducing hypothalamic IKKβ/NF-κB activation and ER stress, thus improving insulin and leptin action in an IL-6- and IL-10-dependent manner...
Arigo completo aqui: http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000465
P.S. Se derrotarmos o organismo remoso acabaremos com 99% dos problemas da humanidade!
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